Experimental Infection of Squirrel Monkeys with Nipah Virus

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Experimental Infection of Squirrel Monkeys with Nipah Virus

We infected squirrel monkeys (Saimiri sciureus) with Nipah virus to determine the monkeys' suitability for use as primate models in preclinical testing of preventive and therapeutic treatments. Infection of squirrel monkeys through intravenous injection was followed by high death rates associated with acute neurologic and respiratory illness and viral RNA and antigen production.

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Nipah Virus Infection

Nipah virus infection is an emerging disease endemic in Southeast Asia. This virus is carried subclinically in fruit bats of the genus Pteropus, a host to which it seems well adapted. Illnesses caused by Nipah virus were first described in 19981999, during widespread outbreaks among pigs and people in Malaysia. The virus had apparently been transmitted from bats to pigs around 1996, and was the...

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Nipah Virus Infection

Nipah virus infection is an emerging disease endemic in Southeast Asia. This virus is carried subclinically in fruit bats of the genus Pteropus, a host to which it seems well adapted. Illnesses caused by Nipah virus were first described in 19981999, during widespread outbreaks among pigs and people in Malaysia. The virus had apparently been transmitted from bats to pigs around 1996, and was the...

متن کامل

Nipah Virus Infection

Nipah virus infection is an emerging disease endemic in Southeast Asia. This virus is carried in fruit bats of the genus Pteropus, a host to which it seems well adapted. It emerges periodically to affect humans, pigs and occasionally other domesticated animals. Nipah virus infections were first described during widespread outbreaks that occurred in Malaysia in 1998-1999. The virus had apparentl...

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Experimental infection of squirrel and marmoset monkeys with attenuated Herpesvirus saimiri.

Herpesvirus saimiri (HVS) was propagated in vero cells for 3 passages at 39 degrees and cloned 3 times at 34 degrees. This virus was inoculated into cotton-topped marmoset and squirrel monkeys; all inoculated monkeys became infected as HVS was reisolated after their circulating lymphocytes were cultured with vero cells and measurable levels of antiviral antibodies developed that were measured b...

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ژورنال

عنوان ژورنال: Emerging Infectious Diseases

سال: 2010

ISSN: 1080-6040,1080-6059

DOI: 10.3201/eid1603.091346